Performance of the Self‐Controlled Case Series With Active Comparators for Drug Safety Signal Detection Using the French Administrative Healthcare Database ( <scp>SNDS</scp> )
The SNDS is a useful data source for signal detection, particularly for outcomes captured in hospitals. Using a carefully designed reference set of drug-outcome pairs well suited to the study design, the SCCS achieved satisfactory performance for signal detection in this database. In this study, the use of active comparators improved overall performance at the expense of greatly reduced sensitivity.
Authors
- Andrew Bate (ORCID: https://orcid.org/0000-0003-3151-3653)
- Angel Y. S. Wong (ORCID: https://orcid.org/0000-0002-8618-7333)
- François Haguinet (ORCID: https://orcid.org/0000-0003-4989-3738)
- Ian Douglas (ORCID: https://orcid.org/0000-0002-8970-1406)
- Astrid Coste (ORCID: https://orcid.org/0000-0003-4207-7447)
Institutions
- London School of Hygiene & Tropical Medicine (GB)
- GlaxoSmithKline (Belgium) (BE)
- Center for Non-Communicable Diseases (PK)
Publication Details
- Journal
- Pharmacoepidemiology and Drug Safety
- Published
- 2025-11-01
- DOI
- https://doi.org/10.1002/pds.70224
- Primary Topic
- Pharmacovigilance and Adverse Drug Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- GlaxoSmithKline