MicroRNA‐Enriched Plant‐Derived Exosomes Alleviate Colitis by Modulating Systemic Immunity, Metabolic Homeostasis, and Gut Microbiota (Adv. Sci. 42/2025)
Plant-DeriveD exosomesRooted in millennia-old herbal wisdom, plant-derived exosomes emerge as potent regulators of uncontrolled inflammatory cascades in colitis.Like turbulent crimson waters surging from the upstream Yarlung Tsangpo Dam, inflammation disrupts mucosal equilibrium.Yet, Nezha, depicted on lotus leaves, releases plant-derived exosomes enriched with miRNAs through a metaphorical conduit.This natural cross-kingdom dialogue transforms pathological chaos into physiological harmony, restoring immune balance, metabolic balance, and gut microbial symbiosis.
Authors
- Haochun Jin
- Guozhen Cui (ORCID: https://orcid.org/0000-0002-7639-2456)
- Zhangfeng Zhong (ORCID: https://orcid.org/0009-0001-1478-3160)
- Si San Lei
- Yitao Wang
- Shuheng Chan
- Dong‐Hua Yang (ORCID: https://orcid.org/0000-0001-8649-5531)
- Ruipeng Shi (ORCID: https://orcid.org/0009-0006-3081-0268)
- Wei Li (ORCID: https://orcid.org/0000-0001-6843-1980)
- Wen Tan (ORCID: https://orcid.org/0000-0003-0895-1604)
Publication Details
- Journal
- Advanced Science
- Published
- 2025-11-01
- DOI
- https://doi.org/10.1002/advs.72372
- Citations
- 3
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 2.42