Fibroblast Growth Factor 2-engaged cell spheroid for stem cell therapy: role of Interleukin 8 in the immune-modulatory effectiveness in the critical limb ischemia model
Our findings underscore the dual role of IL8 in safeguarding muscle tissues from degeneration and orchestrating immunomodulatory effects by finely tuning tissue inflammation and macrophage polarization. This study highlights IL8 as a pivotal paracrine factor contributing to tissue regeneration in the context of stem cell therapy for CLI.
Authors
- Yunji Joo (ORCID: https://orcid.org/0000-0002-7572-4084)
- Jongwan Kim (ORCID: https://orcid.org/0000-0002-9662-5755)
- Eunjoo Kim (ORCID: https://orcid.org/0000-0001-5328-1182)
- Sang‐Heon Kim (ORCID: https://orcid.org/0000-0002-6128-8218)
Institutions
- Bio-Medical Science (South Korea) (KR)
- Ewha Biomedics (South Korea) (KR)
- Korea Institute of Science and Technology (KR)
- Korea University of Science and Technology (KR)
Publication Details
- Journal
- Stem Cells Translational Medicine
- Published
- 2025-11-01
- DOI
- https://doi.org/10.1093/stcltm/szaf051
- Primary Topic
- Muscle Physiology and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00