The Unexpected Protective Role of Thrombosis in Lung Injury via Endothelial Alox15
We have demonstrated that moderate levels of lung thrombosis protect against sepsis-induced inflammatory lung injury via endothelial Alox15. Overexpression of endothelial Alox15 inhibits severe pulmonary thrombosis-induced increases in ALI. Thus, upregulation of ALOX15 expression or treatment with ALOX15-dependent protective lipid(s) represents a promising therapeutic strategy for treatment of ARDS, especially in subpopulations of patients with thrombocytopenia or widespread pulmonary thrombosis.
Authors
- Colin E. Evans (ORCID: https://orcid.org/0000-0002-9251-357X)
- Mrinmay Chakrabarti (ORCID: https://orcid.org/0000-0002-2681-6134)
- Suman Behera (ORCID: https://orcid.org/0000-0003-3797-1014)
- Narsa Machireddy (ORCID: https://orcid.org/0000-0002-9929-7144)
- Rana Dhar (ORCID: https://orcid.org/0000-0001-6283-8018)
- You‐Yang Zhao (ORCID: https://orcid.org/0000-0002-0041-0339)
- Kefyalew Dagnew Addisu (ORCID: https://orcid.org/0000-0002-7609-8476)
- Bowen Wang (ORCID: https://orcid.org/0000-0003-1378-6594)
- Odile David (ORCID: https://orcid.org/0000-0002-6539-2573)
- Xianming Zhang (ORCID: https://orcid.org/0009-0009-1175-7109)
- M. Laurie Phillips (ORCID: https://orcid.org/0009-0009-0508-5043)
Institutions
- Northwestern University (US)
- University of South Carolina (US)
- University of Illinois Chicago (US)
- Lurie Children's Hospital (US)
Publication Details
- Journal
- Circulation Research
- Published
- 2025-11-14
- DOI
- https://doi.org/10.1161/circresaha.125.326357
- Primary Topic
- Immune Response and Inflammation
- Type
- article
- Field-Weighted Citation Impact
- 0.00