Blood Biomarkers for Large Vessel Occlusions: A Systematic Review
The review highlights the critical role of biomarker blood testing to enhance LVO diagnosis, especially in acute clinical settings. Coagulation and hemostasis markers such as D-dimer offer rapid thrombus detection, and acute brain injury and angiogenic biomarkers provide insight into the extent of injury, localization, and vascular response. A combination of biomarkers from multiple categories is needed to provide an accurate clinical picture of LVO in patients. Excluding studies on embolic strokes, including cardioembolic subtypes, may also bias findings by neglecting their distinct biomarker profiles, warranting further investigation to fully assess biomarker utility across stroke etiologies. Despite promising results for multiple biomarkers, including glial fibrillary acidic protein, ubiquitin C-terminal hydrolase-L1, and D-dimer, further research is needed to validate these biomarkers in diverse populations and integrate them into clinical practice effectively.
Authors
- Joshua S. Catapano (ORCID: https://orcid.org/0000-0001-6599-0269)
- Kyle W. Scott (ORCID: https://orcid.org/0000-0002-0017-7522)
- Scott Eric Kasner (ORCID: https://orcid.org/0000-0003-0418-6917)
- Visish Mani Srinivasan (ORCID: https://orcid.org/0000-0001-7673-6805)
- Rashad Jabarkheel (ORCID: https://orcid.org/0000-0002-7643-2622)
- Jan‐Karl Burkhardt
- Ruchira Menka Jha (ORCID: https://orcid.org/0000-0002-3047-7649)
- Shray Patel (ORCID: https://orcid.org/0000-0002-3600-3620)
- Avi A. Gajjar (ORCID: https://orcid.org/0000-0003-3686-9413)
- Adam T. Eberle (ORCID: https://orcid.org/0009-0003-3905-7338)
- Oscar A. Marcos‐Contreras (ORCID: https://orcid.org/0000-0002-1247-4882)
- Saarang Patel
- Ganesh Chilukuri
- Bryan Pukenas (ORCID: https://orcid.org/0000-0001-7452-6804)
- Ilayda Kayir
- T Italia
Institutions
- Bahçeşehir University (TR)
- St. Joseph's Hospital and Medical Center (US)
- Thomas Jefferson University (US)
- Hospital of the University of Pennsylvania (US)
- California University of Pennsylvania (US)
- Translational Therapeutics (United States) (US)
- Drexel University (US)
- University of Pennsylvania (US)
Publication Details
- Journal
- Stroke Vascular and Interventional Neurology
- Published
- 2025-11-01
- DOI
- https://doi.org/10.1161/svin.125.001863
- Primary Topic
- Acute Ischemic Stroke Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00