Lactobacillus reuteri-derived HDCA suppresses PEDV replication while alleviating virus-triggered inflammation in piglets
This study establishes the <i>L. reuteri</i>-HDCA-TGR5-IFNβ-ISG15 metabolic axis as a novel antiviral pathway. This study identified microbial-derived HDCA as a key effector metabolite that mediates protection against PEDV through the coordinated suppression of inflammation and enhancement of antiviral defenses. These findings highlight microbial-metabolic crosstalk as a promising therapeutic strategy against enteric coronaviruses and provide foundational evidence for commensal-derived interventions to manage porcine epidemic diarrhea.
Authors
- Shao‐Lun Zhai (ORCID: https://orcid.org/0000-0003-3217-2256)
- Huahua Kang
- Pinpin Chu
- Zhibiao Bian
- Hongchao Gou
- Zhi‐Yong Jiang (ORCID: https://orcid.org/0000-0002-1715-268X)
- Yan Li (ORCID: https://orcid.org/0000-0001-6180-7076)
- Qianqian Li (ORCID: https://orcid.org/0000-0002-8974-9768)
- Chunling Li (ORCID: https://orcid.org/0000-0003-4612-428X)
- Guang‐Hui Zhao (ORCID: https://orcid.org/0000-0002-3511-6332)
Institutions
- Guangdong Academy of Agricultural Sciences (CN)
- Guangdong Provincial Center for Disease Control and Prevention (CN)
- Northwest A&F University (CN)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2025-11-12
- DOI
- https://doi.org/10.3389/fmicb.2025.1669658
- Primary Topic
- Animal Virus Infections Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00