Evaluating the Immune Response in Rabbits to an Escalating Dose of mRNA-Based HIV-1 Env Immunogens
These results highlight the challenges in eliciting broad and potent neutralizing antibody (nAb) responses. Our findings underscore the need for the continued development and refinement of immunogen design and delivery strategies to guide the elicitation of nAb.
Authors
- Gary R. Matyas (ORCID: https://orcid.org/0000-0002-2074-2373)
- Durgadevi Parthasarathy (ORCID: https://orcid.org/0000-0001-6105-1192)
- Alon Herschhorn (ORCID: https://orcid.org/0000-0002-9323-4820)
- Tashina C. Picard
- Mangala Rao (ORCID: https://orcid.org/0000-0001-9553-4969)
- Shamim Ahmed (ORCID: https://orcid.org/0000-0002-6333-5372)
Institutions
- University of Minnesota (US)
- Walter Reed Army Institute of Research (US)
Publication Details
- Journal
- Vaccines
- Published
- 2025-11-14
- DOI
- https://doi.org/10.3390/vaccines13111161
- Primary Topic
- HIV Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00