HMGB1/NF-κB Axis, IL-8, and Cuproptosis Contribute to Cisplatin-Induced Testicular Injury: Protective Potential Effect of Thymol
Collectively, this study provides evidence of the possible potential role of the HMGB1/NF-κB axis and cuproptosis in CP-induced testicular injury and illustrates the protective effects of thymol against testicular damage, which are attributed, at least in part, to blunting HMGB1 and cuproptosis-related genes expression.
Authors
- Qamraa H. Alqahtani (ORCID: https://orcid.org/0000-0002-6538-9710)
- Aliyah Almomen (ORCID: https://orcid.org/0000-0002-0181-6330)
- Reem T. Atawia
- Amul M. Badr (ORCID: https://orcid.org/0000-0001-9819-0786)
- Yasmen F. Mahran
- Iman H. Hasan (ORCID: https://orcid.org/0000-0001-7311-1412)
- Layla A. Al‐Kharashi (ORCID: https://orcid.org/0000-0003-3171-771X)
- Rehab Ali (ORCID: https://orcid.org/0000-0002-9434-1281)
- Awatif A. Binmughram
- Nadrah Alamri
Institutions
- Ain Shams University (EG)
- Cairo University (EG)
- Southwestern Oklahoma State University (US)
- King Saud University (SA)
Publication Details
- Journal
- Biomolecules
- Published
- 2025-11-14
- DOI
- https://doi.org/10.3390/biom15111595
- Citations
- 1
- Primary Topic
- Chemotherapy-induced organ toxicity mitigation
- Type
- article
- Field-Weighted Citation Impact
- 1.47
Funders
- King Saud University