Targeting GPX4-dependent ferroptosis by natural compounds in multiple sclerosis
Multiple sclerosis (MS) is an autoimmune-mediated, heterogeneous, multifactorial central nervous system degenerative disease influenced by genetics and environment. Ferroptosis, an iron-dependent lipid peroxidation/reactive oxygen species-induced programmed cell death, exacerbates MS pathology. Glutathione peroxidase 4 (GPX4) regulates ferroptosis by clearing peroxides to sustain cells. Targeting GPX4-mediated ferroptosis, especially via safe, potent natural compounds, is a promising MS treatment. This review explores GPX4-dependent ferroptosis's role in MS progression and summarizes natural compounds for MS therapy.
Authors
- Yueqi Jiang (ORCID: https://orcid.org/0000-0001-7900-3084)
- JinRong Wang (ORCID: https://orcid.org/0000-0002-6642-1946)
- Meng‐Liang Zhou (ORCID: https://orcid.org/0000-0002-1165-5489)
- Qiu-Zhu Chen
- Shousong Cao (ORCID: https://orcid.org/0000-0001-6892-0143)
- Caixia Zang
- Yang Dong (ORCID: https://orcid.org/0000-0001-6212-3055)
- Shaohua Zeng (ORCID: https://orcid.org/0000-0003-4018-7933)
- Jingwei Ma (ORCID: https://orcid.org/0000-0002-8854-9756)
- Yang Yang (ORCID: https://orcid.org/0000-0001-6417-3654)
- Dan Zhang (ORCID: https://orcid.org/0000-0001-7970-8332)
- Fangfang Li (ORCID: https://orcid.org/0000-0001-9841-8285)
- Xing Yang (ORCID: https://orcid.org/0000-0001-5541-8832)
- Ning Zhou
- Xiu-Qi Bao
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
Publication Details
- Journal
- Journal of Asian Natural Products Research
- Published
- 2025-11-13
- DOI
- https://doi.org/10.1080/10286020.2025.2576660
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00