Pharmacogenetic markers of PEG-asparaginase toxicity in Brazilian pediatric ALL: insights from a multicenter prospective cohort study
No statistically significant associations were observed between the selected variants and PEG-ASNase-related hypersensitivity or pancreatitis in this cohort.This study highlights the importance of ancestry-informed approaches in pharmacogenomic research for ALL.
Authors
- Lílian Maria Cristófani
- Daiane Keller Cecconello (ORCID: https://orcid.org/0000-0002-2796-6708)
- Mecneide Mendes Lins (ORCID: https://orcid.org/0000-0002-9155-5030)
- Tais Tereziano Barros (ORCID: https://orcid.org/0000-0002-6580-2042)
- Isis Maria Quezado Soares Magalhães
- Sidnei Epelman (ORCID: https://orcid.org/0000-0002-6656-2992)
- Ariani Impieri de Souza (ORCID: https://orcid.org/0000-0002-7917-5983)
- Luíz Felipe Pinho Moreira (ORCID: https://orcid.org/0000-0003-0179-4976)
- Mara Albonei Dudeque Pianovski (ORCID: https://orcid.org/0000-0003-0260-8506)
- Klerize Anecely de Souza Silva (ORCID: https://orcid.org/0000-0002-2424-0354)
- Ciliana Rechenmacher (ORCID: https://orcid.org/0000-0002-1321-5807)
- Liane Esteves Daudt (ORCID: https://orcid.org/0000-0001-9495-6932)
- Mariana Bohns Michalowski (ORCID: https://orcid.org/0000-0002-9482-0776)
- Ana Virgínia Lopes de Sousa
- Evelin Cristine Mendonça de Senna
- Lucas Alfeu Carlotto
Institutions
- Gaertner (United States) (US)
- Universidade Federal do Rio Grande do Sul (BR)
- Support group for adolescents and children with cancer (BR)
- Hospital de Clínicas de Porto Alegre (BR)
- Hospital Erasto Gaertner (BR)
- Instituto de Medicina Integral Professor Fernando Figueira (BR)
- Hospital Amaral Carvalho (BR)
- Hospital Nossa Senhora da Conceição (BR)
- Instituto de Terapia Integrada e Oriental (BR)
Publication Details
- Journal
- Pharmacogenomics
- Published
- 2025-09-22
- DOI
- https://doi.org/10.1080/14622416.2025.2572961
- Primary Topic
- Acute Lymphoblastic Leukemia research
- Type
- article
- Field-Weighted Citation Impact
- 0.00