Effect of Replacing Added Sugars with Sucralose on Gut Microbiome Composition Among Asian Indian Adults in Two 12-week Randomized Controlled Trials
Replacing daily sucrose added to coffee and tea with sucralose resulted in changes in gut microbiome community structure and taxonomic composition among Asian Indian adults with T2D, but not those with overweight/obesity and no T2D. Further studies are needed to understand potential health implications and the underlying drivers of these gut microbiome changes.Clinical Trial Register No. (India Trial Register): CTRI/2021/04/032686, CTRI/2021/04/032809.
Authors
- Jessica Ann Lasky-Su (ORCID: https://orcid.org/0000-0001-6236-4705)
- Jacqueline R. Starr (ORCID: https://orcid.org/0000-0002-3039-2311)
- R. Gayathri (ORCID: https://orcid.org/0000-0002-3377-0461)
- Kuppan Gokulakrishnan (ORCID: https://orcid.org/0000-0003-3167-8239)
- Valangaiman Sriram Manasa (ORCID: https://orcid.org/0009-0005-3019-789X)
- Vasudevan Sudha (ORCID: https://orcid.org/0000-0003-1382-0609)
- Kuzhandaivelu Abirami
- Danielle E. Haslam (ORCID: https://orcid.org/0000-0003-0144-3287)
- Kamala Krishnaswamy
- Shilpa N Bhupathiraju (ORCID: https://orcid.org/0000-0003-0173-9248)
- Frank B. Hu
- Ranjit Unnikrishnan
- Ranjit Mohan Anjana
- Eric B. Rimm
- Viswanathan Mohan
Institutions
- Brigham and Women's Hospital (US)
- Harvard University (US)
- Madras Diabetes Research Foundation (IN)
- Dr. Mohan's Diabetes Specialities Centre (IN)
- National Institute of Mental Health and Neurosciences (IN)
Publication Details
- Journal
- Current Developments in Nutrition
- Published
- 2025-11-14
- DOI
- https://doi.org/10.1016/j.cdnut.2025.107600
- Primary Topic
- Coffee research and impacts
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health