Serum uric acid mediates the association between the estimated glucose disposal rate and chronic kidney disease in patients with diabetes or prediabetes: an analysis from NHANES 2005–2018
This cross-sectional study confirmed that the eGDR is linearly negatively correlated with CKD in a population with diabetes or prediabetes and that its discriminative power is moderate but superior to that of traditional IR indicators. The statistical overlap of SUA on the total association was approximately 6.2%, but the mediating effect was fragile. This finding should be verified in prospective cohorts in the future.
Authors
- Jieyun Yin (ORCID: https://orcid.org/0000-0001-7253-2661)
- Haihua Zhu (ORCID: https://orcid.org/0000-0003-4735-8459)
- Qingan Fu
- Meiling Luo
Institutions
- Nanchang University (CN)
- Jinggangshan University (CN)
- Second Affiliated Hospital of Nanchang University (CN)
Publication Details
- Journal
- BMC Endocrine Disorders
- Published
- 2025-11-13
- DOI
- https://doi.org/10.1186/s12902-025-02081-1
- Citations
- 1
- Primary Topic
- Gout, Hyperuricemia, Uric Acid
- Type
- article
- Field-Weighted Citation Impact
- 1.43