Adenosine in the Brain: Recent Progress on Detection, Function, and Translation

Although adenosine was identified in the brain many decades ago, our understanding of when, where, and how it functions has expanded rapidly in recent years, driven in part by innovative technological advances. Adenosine is now increasingly recognized as a key neuromodulator that dynamically regulates brain circuits important for sleep/wakefulness, movement, cognition, and homeostasis. In addition, growing attention has been directed toward the molecular mechanisms governing adenosine production and its downstream signaling pathways, both of which hold great promise as therapeutic targets for neuropsychiatric disorders and neurodegenerative diseases. This review highlights recent progress in detecting adenosine, unraveling its signaling pathways in vitro and in vivo, and understanding how it regulates brain function under physiological and pathological conditions.

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Publication Details

Journal
Journal of Neuroscience
Published
2025-11-12
DOI
https://doi.org/10.1523/jneurosci.1377-25.2025
Citations
2
Primary Topic
Adenosine and Purinergic Signaling
Type
article
Field-Weighted Citation Impact
2.24
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article

Adenosine in the Brain: Recent Progress on Detection, Function, and Translation

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2 citations
Journal of Neuroscience
Adenosine and Purinergic Signaling
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article

Adenosine in the Brain: Recent Progress on Detection, Function, and Translation

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article en
2 citations

Abstract

Although adenosine was identified in the brain many decades ago, our understanding of when, where, and how it functions has expanded rapidly in recent years, driven in part by innovative technological advances. Adenosine is now increasingly recognized as a key neuromodulator that dynamically regulates brain circuits important for sleep/wakefulness, movement, cognition, and homeostasis. In addition, growing attention has been directed toward the molecular mechanisms governing adenosine production and its downstream signaling pathways, both of which hold great promise as therapeutic targets for neuropsychiatric disorders and neurodegenerative diseases. This review highlights recent progress in detecting adenosine, unraveling its signaling pathways in vitro and in vivo, and understanding how it regulates brain function under physiological and pathological conditions.

Journal of NeuroscienceVol. 45(46)
University of Lisbon (PT), Oregon Health & Science University (US), Wenzhou Medical University (CN), Vollum Institute (US), University of Oxford (GB), Institute of Genetics and Developmental Biology (CN), Max Planck Institute for Biology of Ageing (DE), Institute for Molecular Medicine (US), Research Network (United States) (US), University of Chinese Academy of Sciences (CN), Instituto Gulbenkian de Ciência (PT), Rockefeller University (US), Icahn School of Medicine at Mount Sinai (US)
Openalex Percentile: Top 11%
Adenosine and Purinergic Signaling
2.24
DOISourceOpenAlex
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