Transplantation of hiPSC-derived pericytes rescues Alzheimer’s disease phenotypes in APOE4/4 mice through IGF2-rich apoptotic vesicles
APOE3/3 pericytes or APOE3/3 pericyte-derived IGF2-rich ApoVs may offer promising therapeutic strategies for APOE4-associated AD.
Authors
- Wenjin Ye (ORCID: https://orcid.org/0000-0002-5638-7334)
- Qiumin Chen (ORCID: https://orcid.org/0000-0003-1635-341X)
- Yuanchen Ma (ORCID: https://orcid.org/0000-0001-8109-5037)
- Andy Peng Xiang (ORCID: https://orcid.org/0000-0003-3409-5012)
- Junhua Chen (ORCID: https://orcid.org/0009-0000-1401-2596)
- Mingming Fan (ORCID: https://orcid.org/0009-0002-5757-899X)
- Dairui Li
- Zhengqi Lu
- Yaoliang Tang (ORCID: https://orcid.org/0000-0002-8372-1545)
- Xuejiao Men
- Weijun Huang (ORCID: https://orcid.org/0000-0001-5641-2272)
- Yunfeng Shen (ORCID: https://orcid.org/0000-0003-3404-8400)
- Chuanfeng Xiong (ORCID: https://orcid.org/0000-0002-0383-7004)
- Zhaoran Dong
- Hong Chen (ORCID: https://orcid.org/0009-0009-2906-5514)
- Xiaoyong Chen (ORCID: https://orcid.org/0000-0003-4205-3613)
- Weiqiang Li (ORCID: https://orcid.org/0000-0003-4741-6778)
- Yanming Chen (ORCID: https://orcid.org/0000-0001-6255-0938)
- Lan Wei (ORCID: https://orcid.org/0000-0002-8502-5498)
- Xingqiang Lai
Institutions
- Sun Yat-sen University (CN)
- Guangzhou Development Zone Hospital (CN)
- Third Affiliated Hospital of Sun Yat-sen University (CN)
- Eighth Affiliated Hospital of Sun Yat-sen University
Publication Details
- Journal
- Translational Neurodegeneration
- Published
- 2025-11-13
- DOI
- https://doi.org/10.1186/s40035-025-00512-6
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00