Eligibility for lecanemab and donanemab in Korea under Appropriate Use Recommendations
About a fourth of A+ patients in Korea met AUR criteria for anti-amyloid therapy. Donanemab eligibility slightly exceeded lecanemab despite narrower age criteria. MMSE z-score adjustment increased eligibility in older, less-educated individuals. Over 30% of eligible patients were excluded due to ARIA-related MRI findings. Culturally adapted cognitive thresholds are essential for equitable treatment access.
Authors
- Yoon Young Chang (ORCID: https://orcid.org/0009-0006-0279-1880)
- Gijung Jung (ORCID: https://orcid.org/0000-0001-5952-3373)
- Bo Kyung Sohn (ORCID: https://orcid.org/0000-0002-1444-1099)
- Nayeong Kong (ORCID: https://orcid.org/0000-0002-9095-1701)
- Y. Kim (ORCID: https://orcid.org/0000-0001-5499-1063)
- So Yeon Jeon (ORCID: https://orcid.org/0000-0002-3656-1593)
- Keon Wook Kang (ORCID: https://orcid.org/0000-0003-2622-9017)
- Jee Eun Park (ORCID: https://orcid.org/0000-0001-6097-3275)
- Min Soo Byun (ORCID: https://orcid.org/0000-0003-3159-4510)
- Joon Hyung Jung (ORCID: https://orcid.org/0000-0003-1669-6113)
- Hongyoon Choi (ORCID: https://orcid.org/0000-0002-8895-2449)
- Hyejin Ahn (ORCID: https://orcid.org/0000-0002-6613-4680)
- Dahyun Yi (ORCID: https://orcid.org/0000-0002-0860-0946)
- Chul‐Ho Sohn (ORCID: https://orcid.org/0000-0003-0039-5746)
- Dong Young Lee (ORCID: https://orcid.org/0000-0001-8976-8320)
- Hye Ji Choi
- Y. J. Oh
- Chung Hee Gwag
Institutions
- Seoul National University (KR)
- New Generation University College (ET)
- Seoul National University Hospital (KR)
- Seoul Medical Center (KR)
- SNUH SMG-SNU Boramae Medical Center (KR)
- Inje University Sanggye Paik Hospital (KR)
- Hallym University Dongtan Sacred Heart Hospital (KR)
- Chungbuk National University Hospital (KR)
- Keimyung University (KR)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-11-01
- DOI
- https://doi.org/10.1002/alz.70875
- Citations
- 1
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 1.47
Funders
- National Research Foundation
- Seoul National University
- Korea Health Industry Development Institute
- National Research Foundation of Korea
- Ministry of Science and ICT, South Korea