Association between ischemic stroke, hemorrhagic stroke, dementia, and rs201118034 among general Taiwanese population
The study utilized data from over 114,000 individuals in the Taiwan Biobank, integrating clinical diagnoses and genetic information for robust statistical analysis. The rs201118034 AG+AA genotype in the NOTCH3 gene significantly increased the risk of ischemic stroke and hemorrhagic stroke. This variant shows no significant association with dementia, emphasizing the distinct pathways involved in cerebrovascular diseases and cognitive decline.
Authors
- Che‐Hong Chen (ORCID: https://orcid.org/0000-0003-0765-0893)
- Yung‐Po Liaw (ORCID: https://orcid.org/0000-0003-2046-4964)
- Yi‐Chia Liaw
- Yi‐Ching Liaw
- Shu‐Yi Hsu (ORCID: https://orcid.org/0000-0003-3359-3714)
Institutions
- National Yang Ming Chiao Tung University (TW)
- China Medical University (TW)
- National Yang Ming University Hospital (TW)
- Chung Shan Medical University Hospital (TW)
- China Medical University Hospital (TW)
- Chung Shan Medical University (TW)
- Stanford University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-11-01
- DOI
- https://doi.org/10.1002/alz.70453
- Primary Topic
- Cerebrovascular and genetic disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Taiwan Biobank
- Ministry of Science and Technology, Taiwan
- Health and Welfare Data Science Center
- National Science and Technology Council