Eco-friendly fast-facile synthesis of single-phase hydroxyapatite nanoparticles by liquid flame spray method

Environmentally sustainable aspects and high demand for hydroxyapatite (HA) nanoparticles engendered the development of an eco-friendly, simple, scalable, adjustable, fast, and continuous pathway for generation of phase-pure HA nanoparticles. This work presents a newly developed flame aerosol synthesis method, Liquid Flame Spray (LFS), for HA nanoparticle production. LFS involves feeding a precursor solution into a hydrogen-oxygen flame, providing a process that can meet all the criteria mentioned above. In this study, the single-phase HA nanoparticles were successfully synthesized feeding a water-based precursor into the flame without using any organic solvents and/or surfactants. The flame-made HA nanoparticles were ca. 8 nm in diameter with as high surface area as 250.3 .