Comparison of organ dysfunction patterns in pediatric hemophagocytic lymphohistiocytosis and sepsis: incidence, adverse outcomes, and cluster characteristics
The incidence, adverse outcome rates, and clustering patterns of organ dysfunction differed between HLH and severe sepsis. Strategies to improve prognosis should vary for each condition. In HLH, preventing the development of severe organ dysfunction is crucial, whereas in severe sepsis, the emphasis should be on preventing the clustering of multiple complications.
Authors
- Jiaotian Huang
- Haixia Yang (ORCID: https://orcid.org/0000-0002-4410-9257)
- Longlong Xie (ORCID: https://orcid.org/0000-0002-5690-9083)
- Zhenghui Xiao (ORCID: https://orcid.org/0000-0001-6308-9688)
- Xun Li (ORCID: https://orcid.org/0000-0002-5070-8950)
- Xiangyu Wang (ORCID: https://orcid.org/0000-0003-4078-3620)
- Luo Haiyan
- Xinping Zhang (ORCID: https://orcid.org/0000-0001-6534-0004)
- Xiao Li (ORCID: https://orcid.org/0000-0001-6894-7370)
- Xiulan Lu
- Yufan Yang (ORCID: https://orcid.org/0000-0002-5042-9564)
- Haipeng Yan
- Jin-peng Gan
- Ting Luo
Institutions
- Central South University (CN)
- Hunan Children's Hospital (CN)
- University of South China (CN)
Publication Details
- Journal
- Frontiers in Pediatrics
- Published
- 2025-11-13
- DOI
- https://doi.org/10.3389/fped.2025.1708908
- Primary Topic
- Autoimmune and Inflammatory Disorders Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Hunan Province
- Young Scientists Fund