Changed expression of placental transporters and disrupted epigenetic patterns in a rat model of schizophrenia

Based on our results, we can conclude that the expression and function of the placental efflux proteins we examined are altered in schizophrenia, and possibly as a result, altered substrate concentrations were measured in the fetuses. We hypothesize that the altered protein expression may also be a result of the disease-induced epigenetic pattern changes. This study presents novel disease-associated placental ABC transporter alterations, which highlights the dangers of using transporter substrates, especially P-gp, during pregnancy.