Fibroblast growth factor 18 stimulates chondrocyte proliferation by modulating FOXN2 to mitigate post-traumatic osteoarthritis in a mouse model
These findings highlight that FGF18 mitigates PTOA progression by targeting FOXN2, promoting robust aggrecan synthesis, and substantially suppressing cartilage-degrading enzymes. Our study delineates a novel therapeutic axis for PTOA, emphasizing the distinct molecular mechanisms underlying trauma-driven cartilage pathology.
Authors
- Yu Lin (ORCID: https://orcid.org/0000-0001-6579-484X)
- Zhusong Huang (ORCID: https://orcid.org/0000-0001-9434-133X)
- Jinfu Lan (ORCID: https://orcid.org/0000-0001-7094-6625)
- Wenhan Zhao (ORCID: https://orcid.org/0000-0002-2858-2378)
- Xi Gao (ORCID: https://orcid.org/0000-0002-6425-1218)
Institutions
- Fuzhou Second Hospital (CN)
Publication Details
- Journal
- Frontiers in Bioengineering and Biotechnology
- Published
- 2025-11-13
- DOI
- https://doi.org/10.3389/fbioe.2025.1615124
- Primary Topic
- Fibroblast Growth Factor Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00