Hidradenitis suppurativa associated with chromosomal abnormalities, genodermatoses and genetic disorders: a review

Hidradenitis suppurativa (HS) is a severe chronic relapsing inflammatory disease of the hair follicle unit, characterized by painful nodules, abscesses, tunnels and tracts in intertriginous areas. Although the pathogenic mechanisms of HS have not yet been fully elucidated, genetics is a central component of its pathogenesis, and understanding relevant genetic factors is essential for gaining insights into the molecular mechanisms of HS. We conducted a comprehensive review of common and rare associations between HS and chromosomal and genetic diseases, exploring the pathogenetic links between these diseases. Although rare, the well-documented associations of HS with chromosomal abnormalities, monogenic disorders, genodermatoses and autoinflammatory conditions, many of which are characterized by follicular hyperkeratinization and epidermal hyperproliferation, may provide important insights into HS pathomechanisms and facilitate the identification of novel genetic factors contributing to disease susceptibility.