P2RX1 Influences the Prognosis of Ph+/Ph-Like ALL through Energy and Calcium Metabolism
Our findings indicate that P2RX1 may exert this function through modulating energy metabolism and calcium homeostasis, resulting in elevated intracellular calcium levels. Sustained elevation of calcium promotes apoptosis, whereas exogenous ATP activates P2RX1, enhances calcium influx, and attenuates the suppression of apoptosis associated with P2RX1 underexpression, ultimately correlating with improved treatment response.
Authors
- Xin Lian (ORCID: https://orcid.org/0000-0002-7369-247X)
- Biqi Yang
- Likun Zhang (ORCID: https://orcid.org/0000-0003-3898-6533)
- Yuqing Ye (ORCID: https://orcid.org/0000-0002-4217-8849)
- Yujuan Gao (ORCID: https://orcid.org/0000-0003-0650-3218)
- Yang Liu (ORCID: https://orcid.org/0000-0002-2517-9436)
- Xın Zhang (ORCID: https://orcid.org/0000-0002-3648-7776)
- Xiaobing Li (ORCID: https://orcid.org/0000-0001-9105-6365)
- Zhiyu Liu (ORCID: https://orcid.org/0000-0002-1678-5960)
- Li Feng (ORCID: https://orcid.org/0000-0003-2898-8308)
- Qin Ren
- Peng Song (ORCID: https://orcid.org/0000-0002-1748-5580)
- Huiqiong Tang
- Lanlan Wei
- X. Ye
Institutions
- Harbin Medical University (CN)
- Southern University of Science and Technology (CN)
- Guangzhou Experimental Station (CN)
- First Affiliated Hospital of Heilongjiang University of Chinese Medicine (CN)
- First Affiliated Hospital of Harbin Medical University (CN)
- Shenzhen Third People’s Hospital (CN)
Publication Details
- Journal
- Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics
- Published
- 2025-11-14
- DOI
- https://doi.org/10.32604/or.2025.068814
- Citations
- 1
- Primary Topic
- Ion Transport and Channel Regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.81