Cyclovirobuxine D ameliorates cardiomyocyte senescence in diabetic cardiomyopathy mice by enhancing mitochondrial function via sirtuin 3–ATP5O signal axis
It is the first time that we confirm CVB-D ameliorating cardiomyocyte senescence in DCM by enhancing mitochondria dysfunction through activated SIRT3-ATP5O axis. It also suggests that CVB-D could be employed in the future to treat cardiomyocyte senescence caused by DCM.
Authors
- Ling Tao (ORCID: https://orcid.org/0000-0003-2919-5641)
- Lingyun Fu
- Yongxin Chen (ORCID: https://orcid.org/0000-0002-1459-6365)
- Guangqiong Zhang
- Xiangchun Shen (ORCID: https://orcid.org/0000-0002-4333-9106)
- Xueting Wang (ORCID: https://orcid.org/0000-0001-6141-3077)
- Chengfeng Xiao (ORCID: https://orcid.org/0000-0002-2301-1365)
- Yini Xu
- Long Yang
- Hong Luo (ORCID: https://orcid.org/0009-0009-0443-7326)
- Hang Su (ORCID: https://orcid.org/0009-0003-6834-0087)
- Hong Yang (ORCID: https://orcid.org/0000-0002-8639-8309)
- Jiangfei An
- BarBu Wollenberga
Institutions
- Guiyang College of Traditional Chinese Medicine (CN)
- Guiyang Medical University (CN)
- Guizhou University (CN)
- Affiliated Hospital of Guizhou Medical University (CN)
Publication Details
- Journal
- Chinese Medicine
- Published
- 2025-11-13
- DOI
- https://doi.org/10.1186/s13020-025-01254-3
- Citations
- 1
- Primary Topic
- Sirtuins and Resveratrol in Medicine
- Type
- article
- Field-Weighted Citation Impact
- 1.22
Funders
- National Natural Science Foundation of China