Screening, genetic analysis, and clinical transfusion implications of thalassaemia and glucose‐6‐phosphate dehydrogenase deficiency in blood donors
The -<sup>SEA</sup>/αα genotype is the most prevalent in α-thalassaemia, while c.1388G>A is the most common genetic variant in G6PD deficiency. Individuals with G6PD deficiency exhibit higher MCV and MCH values. Additionally, blood donated by carriers of thalassaemia or G6PD deficiency does not increase the risk of adverse transfusion reactions. The transfusion of blood from donors with thalassaemia or G6PD deficiency showed no significant difference in haemoglobin elevation compared to that from normal donors.
Authors
- Zhi‐Xiao Chen (ORCID: https://orcid.org/0009-0001-6230-1621)
- Li‐Ye Yang (ORCID: https://orcid.org/0000-0003-1581-9089)
- Jiancheng Huang (ORCID: https://orcid.org/0000-0003-2516-088X)
- R Liu
- Mai Zhang (ORCID: https://orcid.org/0000-0001-9835-797X)
- Weifeng Xu (ORCID: https://orcid.org/0000-0001-6682-3075)
- Yu‐Chan Huang
- Baoying Chen
- Jia‐Min Mo
- Yan-qing Zeng
- Bai-ru Lai
- Yu Cao (ORCID: https://orcid.org/0000-0002-9134-8680)
Institutions
- Yancheng Central Blood Station (CN)
- Qujiang People's Hospital (CN)
- People's Hospital of Yangzhong (CN)
Publication Details
- Journal
- Transfusion Medicine
- Published
- 2025-11-12
- DOI
- https://doi.org/10.1111/tme.70018
- Citations
- 1
- Primary Topic
- Hemoglobinopathies and Related Disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.63