C(sp ³ )–H halogenation using first-row transition metal catalysts under homogeneous conditions

The direct functionalization of unactivated C-H bonds has emerged as a promising strategy to achieve step-economical, atom-efficient, and environmentally benign chemical processes. In this context, ongoing research is focused on the design and development of biomimetic homogeneous catalysts based on first-row transition metals for C(sp³)-H halogenation under mild conditions. In essence, this review highlights key advances in catalyst design based on first-row transition metals, showcasing their growing utility in the development of new synthetic methods.