Dual‐center prospective validation of an early second‐trimester predictive model integrating <scp>BMI</scp> trajectories and pathophysiological biomarkers for gestational diabetes risk stratification
This dual-center model pioneers GDM risk stratification by 12-14 weeks using clinically accessible metrics, reducing weight-monitoring frequency without compromising prognostic value. While AUC limitations (0.68-0.69) suggest unmeasured contributors, its operational simplicity and robust negative predictive capacity support implementation in resource-constrained settings. The findings redefine antenatal care paradigms by shifting focus to early metabolic dysregulation rather than late diagnostic thresholds.
Authors
- Yanbei Duo (ORCID: https://orcid.org/0000-0002-9867-9087)
- Xiaorui Nie
- Tao Yuan (ORCID: https://orcid.org/0000-0003-1966-0829)
- Weigang Zhao (ORCID: https://orcid.org/0000-0002-2797-2614)
- Qiujin Sun
- Zechun Lu
- Yong Fu (ORCID: https://orcid.org/0000-0001-6480-1147)
- Yuemei Zhang (ORCID: https://orcid.org/0000-0003-3555-4524)
- Jing Zhang (ORCID: https://orcid.org/0009-0003-9684-8654)
- Mengmeng Zhang (ORCID: https://orcid.org/0000-0001-7632-7702)
- Ailing Wang (ORCID: https://orcid.org/0000-0003-4801-6186)
- Shuoning Song (ORCID: https://orcid.org/0000-0003-4810-4063)
- Yingyue Dong
- Wei Sun (ORCID: https://orcid.org/0009-0005-8101-5697)
- Junxiang Gao
- Xianchun Yang
- Xiaolin Qiao
- Jiyu Xu
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking Union Medical College Hospital (CN)
- Hainan Maternal and Child Health Hospital (CN)
- National Center for Women and Children’s Health, China CDC (CN)
- Beijing Chaoyang Emergency Medical Center (CN)
Publication Details
- Journal
- Journal of Diabetes Investigation
- Published
- 2025-11-12
- DOI
- https://doi.org/10.1111/jdi.70179
- Primary Topic
- Gestational Diabetes Research and Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00