Facile Synthesis of Chiral <i>gem</i> ‐Difluorocyclopropanes via Rhodium‐Catalyzed Hydrogenation
A rhodium‐catalyzed asymmetric hydrogenation of gem ‐difluorocyclopropenyl esters or ketones has been achieved, affording the disubstituted cis ‐ gem ‐difluorocyclopropanes with high enantio‐ and diastereoselectivities (up to 99% ee and >20:1 dr). Furthermore, the hydrogenation proceeds smoothly at gram scale without erosion of activity and enantioselectivity. The chiral gem ‐difluorocyclopropane products could be transformed into chiral building blocks and bioactive molecule.
Authors
- Shijian Yin (ORCID: https://orcid.org/0009-0005-4830-9968)
- Mu‐Wang Chen (ORCID: https://orcid.org/0000-0001-6493-1363)
- Xinsheng Zhang (ORCID: https://orcid.org/0009-0000-2639-2688)
- Yong‐Gui Zhou (ORCID: https://orcid.org/0000-0002-3321-5521)
- Zheng Liu (ORCID: https://orcid.org/0000-0003-0700-4154)
Institutions
- Dalian Institute of Chemical Physics (CN)
- Dalian Medical University (CN)
- Dalian University of Technology (CN)
- Second Affiliated Hospital of Dalian Medical University (CN)
Publication Details
- Journal
- Advanced Synthesis & Catalysis
- Published
- 2025-11-12
- DOI
- https://doi.org/10.1002/adsc.70169
- Primary Topic
- Fluorine in Organic Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Dalian Medical University
- Dalian Institute of Chemical Physics