Augmentation of sertraline with aripiprazole in a case of treatment-resistant skin-picking disorder

Skin picking disorder (SPD) is a chronic psychiatric condition characterized by recurrent self-excoriation behaviors that often lead to marked psychosocial and functional impairment.Although the disorder is relatively prevalent and substantially disabling, therapeutic options for persistent and treatment-resistant cases remain scarce.The present case report discusses a 54-year-old woman with a three-decade history of SPD and coexisting depressive disorder who exhibited significant clinical improvement following combined treatment with sertraline and aripiprazole.This case underscores the potential clinical value of integrating selective serotonin reuptake inhibitors with atypical antipsychotics in addressing refractory forms of SPD.