Multi-layered engineering of Aspergillus terreus enhances biosynthesis of the plant-derived fungicide physcion
This study reveals a detoxification bottleneck in anthraquinone biosynthesis and establishes two improved A. terreus platforms for scalable production of physcion and emodin, respectively, highlighting trade-offs between pathway efficiency and cellular fitness.
Authors
- Yingying Xue (ORCID: https://orcid.org/0000-0003-4529-1801)
- Dandan Feng
- Xuenian Huang (ORCID: https://orcid.org/0000-0002-3130-2701)
- Honglei Ma (ORCID: https://orcid.org/0000-0003-3571-8867)
- Xuefeng Lü (ORCID: https://orcid.org/0000-0002-0570-9196)
- Ning Xu (ORCID: https://orcid.org/0000-0003-1751-9610)
- Dan Liu (ORCID: https://orcid.org/0000-0001-8078-1318)
- Xiaoxi Zhang (ORCID: https://orcid.org/0000-0003-2594-8810)
- Lin Zhao (ORCID: https://orcid.org/0000-0002-6520-5096)
- Feifei Qi (ORCID: https://orcid.org/0000-0002-2937-4909)
- Ce Geng (ORCID: https://orcid.org/0000-0001-9065-6131)
- Z. Z. Ren (ORCID: https://orcid.org/0009-0002-9623-0312)
- Y. M. Wu
Institutions
- Qilu University of Technology (CN)
- Chinese Academy of Sciences (CN)
- University of Jinan (CN)
- Qingdao National Laboratory for Marine Science and Technology (CN)
- Qinghai New Energy (China) (CN)
- Shandong Academy of Sciences (CN)
- Qingdao Institute of Bioenergy and Bioprocess Technology (CN)
- Qingdao Center of Resource Chemistry and New Materials (CN)
- University of Chinese Academy of Sciences (CN)
- Dalian Minzu University (CN)
Publication Details
- Journal
- Microbial Cell Factories
- Published
- 2025-11-13
- DOI
- https://doi.org/10.1186/s12934-025-02857-z
- Primary Topic
- Fungal and yeast genetics research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China