Amide proton transfer-weighted (APTw) CEST MRI in clinical routine for single time point diagnosis of pseudoprogression in IDH-wildtype glioblastoma
APTw MRI is a non-invasive imaging tool that is feasible for clinical routine and aids in differentiation of early progression from pseudoprogression in glioblastoma. Its diagnostic accuracy decreases with application of anti-angiogenic treatment and at later follow-up time points. Highest diagnostic accuracy was found in a multimodal approach combining APTw MRI, PWI and DWI.
Authors
- Florian Kroh (ORCID: https://orcid.org/0000-0001-7387-3206)
- Sebastian Regnery (ORCID: https://orcid.org/0000-0002-6820-884X)
- Eleni Gkika (ORCID: https://orcid.org/0000-0001-5455-252X)
- Christina Schaub (ORCID: https://orcid.org/0000-0002-5257-4183)
- Hartmut Vatter (ORCID: https://orcid.org/0000-0001-9999-7282)
- Jochen Keupp (ORCID: https://orcid.org/0000-0003-2129-1153)
- Mousa Zidan (ORCID: https://orcid.org/0000-0002-5236-3992)
- Julian Philipp Layer (ORCID: https://orcid.org/0000-0001-7692-7775)
- Matthias Schneider (ORCID: https://orcid.org/0000-0002-6025-7479)
- Andreas Decker (ORCID: https://orcid.org/0009-0009-6018-3666)
- Torsten Pietsch (ORCID: https://orcid.org/0000-0003-0763-6506)
- Anna‐Laura Potthoff (ORCID: https://orcid.org/0000-0002-5710-6557)
- Niklaus Schaefer (ORCID: https://orcid.org/0000-0002-9732-7696)
- Ulrich Herrlinger (ORCID: https://orcid.org/0000-0002-4011-9327)
- Thomas Zeyen (ORCID: https://orcid.org/0009-0006-2919-8622)
- Johannes Weller (ORCID: https://orcid.org/0000-0001-5818-5392)
- Christoph Katemann
- Alexander Radbruch (ORCID: https://orcid.org/0000-0001-6238-6525)
- Daniel Paech (ORCID: https://orcid.org/0000-0001-5755-6833)
- Lea L Friker (ORCID: https://orcid.org/0009-0005-5642-9062)
- Inga Krause
Institutions
- Brigham and Women's Hospital (US)
- Heidelberg University (DE)
- University Hospital Bonn (DE)
- German Center for Neurodegenerative Diseases (DE)
- University Hospital Heidelberg (DE)
- Integrated Oncology (United States) (US)
- Universitätsklinikum Knappschaftskrankenhaus Bochum (DE)
- Philips (Germany) (DE)
- Ruhr University Bochum (DE)
Publication Details
- Journal
- Neuro-Oncology
- Published
- 2025-11-13
- DOI
- https://doi.org/10.1093/neuonc/noaf261
- Primary Topic
- Lanthanide and Transition Metal Complexes
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Deutsche Forschungsgemeinschaft
- Rheinische Friedrich-Wilhelms-Universität Bonn