Insulin production is sustained during DNA damage-mediated senescence in adult human beta cells
Our findings suggest that the expression of proinsulin-processing enzymes and the production of insulin are sustained in both chemically induced DNA damage-related senescence and in endogenous senescent adult human beta cells. Collectively, these findings suggest that senescent beta cells may be a source of insulin production among residual beta cells in type 1 diabetes.
Authors
- Peter J. Thompson (ORCID: https://orcid.org/0000-0002-6851-8899)
- C. Bruce Verchere (ORCID: https://orcid.org/0000-0002-9262-0586)
- Jasmine Pipella (ORCID: https://orcid.org/0009-0005-9936-8386)
- Nayara Rampazzo Morelli (ORCID: https://orcid.org/0000-0001-7183-4668)
- Yi‐Chun Chen (ORCID: https://orcid.org/0000-0003-4328-0383)
- Camille Préfontaine (ORCID: https://orcid.org/0009-0002-5802-1560)
Institutions
- University of British Columbia (CA)
- University of Saskatchewan (CA)
- Children's Hospital Research Institute of Manitoba (CA)
- BC Children's Hospital (CA)
- University of Manitoba (CA)
Publication Details
- Journal
- Diabetologia
- Published
- 2025-11-13
- DOI
- https://doi.org/10.1007/s00125-025-06603-3
- Primary Topic
- Pancreatic function and diabetes
- Type
- article
- Field-Weighted Citation Impact
- 0.00