Extracellular microRNAs modulate human microglial function through TLR8
Our data establish that distinct CNS disease-associated miRNAs serve as signaling molecules for human microglia via TLR8, thereby controlling the diverse microglial functions and modulating the neuroinflammatory response.
Authors
- Leonard D. Kuhrt (ORCID: https://orcid.org/0000-0001-7157-6988)
- Silke Frahm (ORCID: https://orcid.org/0000-0001-5645-2557)
- Edyta Motta
- Susanne A. Wolf (ORCID: https://orcid.org/0000-0003-0922-8418)
- Seija Lehnardt (ORCID: https://orcid.org/0000-0002-1068-7112)
- Sebastian Diecke (ORCID: https://orcid.org/0000-0002-5219-5992)
- Hannah Weidling
- Thomas E. Wallach (ORCID: https://orcid.org/0000-0001-6207-1363)
- Caio Andreeta Figueiredo (ORCID: https://orcid.org/0000-0003-1517-5957)
- Helmut Kettenmann (ORCID: https://orcid.org/0000-0001-8208-0291)
- Christina Krüger (ORCID: https://orcid.org/0009-0001-6544-7917)
Institutions
- Helmholtz Association of German Research Centres (DE)
- Shenzhen University (CN)
- Max Delbrück Center (DE)
- University Town of Shenzhen (CN)
- Humboldt-Universität zu Berlin (DE)
- German Centre for Cardiovascular Research (DE)
- Berlin Institute of Health at Charité - Universitätsmedizin Berlin (DE)
- Shenzhen Technology University (CN)
- Otto-von-Guericke-Universität Magdeburg (DE)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-11-14
- DOI
- https://doi.org/10.3389/fimmu.2025.1645062
- Citations
- 1
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.84