A novel carcinogenic mouse model by site‐directed insertion of tandem human <i>HRAS</i> large <scp>DNA</scp> fragment into <scp>15E1</scp> site
The NF-hHRAS mice demonstrated excellent genetic stability, a reproducible phenotype, and high susceptibility to carcinogens, indicating their potential utility in non-clinical safety evaluations of drugs as per the S1B guidelines issued by the ICH (The International Council for Harmonization of Technical Requirements for Pharmaceuticals for Human Use).
Authors
- Suodi Zhai (ORCID: https://orcid.org/0000-0003-2220-359X)
- YuYa Wang
- Wenda Gu
- Guitao Huo
- Susu Liu (ORCID: https://orcid.org/0000-0002-9134-417X)
- Wei Gong (ORCID: https://orcid.org/0000-0001-5889-9184)
- Sanlong Wang (ORCID: https://orcid.org/0009-0005-9455-3056)
- Yuan Cao (ORCID: https://orcid.org/0009-0004-8130-2576)
- Ling Chen (ORCID: https://orcid.org/0000-0003-1485-1626)
- Changfa Fan (ORCID: https://orcid.org/0000-0001-5556-2025)
- Xiaowei Sun
- Yanwei Yang
- Huaqian Zhao
Institutions
- Genetic Resources Center (JP)
- National Institutes for Food and Drug Control (CN)
- Institute of Animal Sciences (CN)
Publication Details
- Journal
- Animal Models and Experimental Medicine
- Published
- 2025-11-01
- DOI
- https://doi.org/10.1002/ame2.70086
- Primary Topic
- Carcinogens and Genotoxicity Assessment
- Type
- article
- Field-Weighted Citation Impact
- 0.00