CDK5 regulates PPARγ/NF-κB signaling to exacerbate obesity-related osteoarthritis via modulating macrophage polarization and chondrocyte apoptosis
CDK5 promotes the progression of obesity-associated OA through the PPARγ/NF-κB pathway and is a potential therapeutic target in OA, especially in obese patients.
Authors
- Jingyue Su (ORCID: https://orcid.org/0000-0002-1369-0173)
- Xin Chen (ORCID: https://orcid.org/0009-0008-8427-3001)
- Shengwu Yang (ORCID: https://orcid.org/0009-0000-8624-7781)
- Zhenhan Deng (ORCID: https://orcid.org/0000-0003-0522-8269)
- Xingfu Li (ORCID: https://orcid.org/0000-0001-5044-8098)
- Hengzhen Li (ORCID: https://orcid.org/0000-0002-1140-3660)
- Yusheng Li (ORCID: https://orcid.org/0009-0006-7414-9053)
- Wen-Feng Xiao (ORCID: https://orcid.org/0000-0001-9030-9922)
Institutions
- Central South University (CN)
- Wenzhou Medical University (CN)
- First Affiliated Hospital of Wenzhou Medical University (CN)
- Xiangya Hospital Central South University (CN)
- Shenzhen Second People's Hospital (CN)
Publication Details
- Journal
- Cellular & Molecular Biology Letters
- Published
- 2025-11-13
- DOI
- https://doi.org/10.1186/s11658-025-00822-7
- Citations
- 1
- Primary Topic
- Peroxisome Proliferator-Activated Receptors
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- Health Commission of Hunan Province
- National Natural Science Foundation of China
- Xiangya Hospital, Central South University
- Basic and Applied Basic Research Foundation of Guangdong Province