Electroacupuncture alleviates cognitive impairments in APP/PS1 mice via gastric vagal afferent-mediated activation of the nucleus tractus solitarius‒locus coeruleus noradrenergic circuit
EA at ST36/ST37 alleviates AD-related cognitive impairment through sequential GVAF-NTS-LC circuit activation and downstream ADRB2/PKA/CREB-mediated neuroinflammatory resolution. This work identifies a previously unrecognized peripheral-central neural circuit mechanism underlying EA's therapeutic efficacy in AD pathogenesis.
Authors
- Chao-Chao Yu (ORCID: https://orcid.org/0000-0003-3216-7473)
- Shan Gao (ORCID: https://orcid.org/0000-0001-7424-476X)
- Yanjun Du (ORCID: https://orcid.org/0000-0002-0762-9077)
- Li Wang (ORCID: https://orcid.org/0000-0003-1918-0040)
- Man Li (ORCID: https://orcid.org/0000-0003-4041-0437)
- Jia Wang (ORCID: https://orcid.org/0000-0002-9544-9366)
- Feng Shen
- Yongchao Wu
- Chuan He
Institutions
- Hubei University of Chinese Medicine (CN)
- Integrated Chinese Medicine (China) (HK)
- Wuhan No.1 Hospital (CN)
- Wuhan Union Hospital (CN)
- Union Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Chinese Medicine
- Published
- 2025-11-13
- DOI
- https://doi.org/10.1186/s13020-025-01230-x
- Citations
- 1
- Primary Topic
- Acupuncture Treatment Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 2.38
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Hubei Province