Temporal glomerular gene expression dynamics during disease progression in a mouse model of hypertension‐accelerated diabetic kidney disease
The db/db UNx-ReninAAV mouse model exhibits distinct temporal dynamics in glomerular cell markers, metabolic dysregulation, ECM remodeling, and injury. Together, these results highlight the utility of the db/db UNx-ReninAAV model as a relevant preclinical platform for studying progressive DKD.
Authors
- Henrik H. Hansen (ORCID: https://orcid.org/0000-0002-3732-0281)
- Ole Jørgen Kaasbøll
- Louise S. Dalbøge (ORCID: https://orcid.org/0000-0001-7773-6313)
- Mette V. Østergaard (ORCID: https://orcid.org/0000-0001-6075-2392)
- Maria Katarina Ougaard (ORCID: https://orcid.org/0000-0003-0226-3405)
- Ditte Hansen (ORCID: https://orcid.org/0000-0003-4929-7901)
- Michael Christensen (ORCID: https://orcid.org/0000-0003-1693-058X)
- Adam Bøgh Marstrand-Jørgensen (ORCID: https://orcid.org/0009-0005-5917-3154)
- Frederikke Emilie Sembach
Institutions
- University of Copenhagen (DK)
- Novo Nordisk (Denmark) (DK)
- Herlev Hospital (DK)
- Gentofte Hospital (DK)
- Gubra (Denmark) (DK)
- Pharmasum Therapeutics (Norway) (NO)
Publication Details
- Journal
- Animal Models and Experimental Medicine
- Published
- 2025-11-13
- DOI
- https://doi.org/10.1002/ame2.70094
- Primary Topic
- Chronic Kidney Disease and Diabetes
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Innovationsfonden