Preclinical assessment of checkpoint blockade combined with DNA methyltransferase inhibition in high-risk pediatric brain tumors reveals limited therapeutic synergy
DAC alone or in combination with a checkpoint inhibitor can alter the immune microenvironment in mouse tumor models. Changes were observed in H3-wildtype DIPG and ATRT models, suggesting that certain tumor subtypes may respond to immune priming with DNMTi.
Authors
- Michele Zeinieh (ORCID: https://orcid.org/0000-0002-0875-2077)
- Fiona Pakiam (ORCID: https://orcid.org/0000-0001-6292-1137)
- Dhana Llivichuzhca-Loja
- Shiva Senthil Kumar
- Caterina Russo (ORCID: https://orcid.org/0000-0002-7770-0457)
- Fupan Yao
- Erin Crotty
- Midori Clarke (ORCID: https://orcid.org/0000-0002-2402-108X)
- Shelli M. Morris
- Emily J. Girard (ORCID: https://orcid.org/0000-0003-1857-0194)
- Andrew Bondoc (ORCID: https://orcid.org/0000-0003-1468-6245)
- Annie Huang (ORCID: https://orcid.org/0000-0002-1987-6980)
- Liza Konnikova (ORCID: https://orcid.org/0000-0003-4804-5497)
- Xiaoting Zhu
- James M. Olson (ORCID: https://orcid.org/0000-0001-5990-6534)
- Rachid Drissi (ORCID: https://orcid.org/0000-0003-0564-0181)
- Margo Coxon
- Banlanjo Abdulaziz Umaru (ORCID: https://orcid.org/0000-0003-4517-2255)
- James T. Rutka (ORCID: https://orcid.org/0000-0003-0851-7330)
- Maryam Fouladi (ORCID: https://orcid.org/0000-0002-5693-035X)
- Nada Jabado (ORCID: https://orcid.org/0000-0003-2485-3692)
- Dean Popovski
- Heather R. Conti (ORCID: https://orcid.org/0000-0002-1491-4212)
- Matthew C. Biery (ORCID: https://orcid.org/0000-0003-3315-982X)
- Mi‐Youn Brusniak (ORCID: https://orcid.org/0000-0003-3950-1614)
- Augusto Faria Andrade (ORCID: https://orcid.org/0000-0001-5866-0501)
- Deepak Mishra (ORCID: https://orcid.org/0000-0001-6867-3904)
- Mei Lu
- Ken Brasel
Institutions
- Nationwide Children's Hospital (US)
- Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa (ZA)
- Hospital for Sick Children (CA)
- McGill University Health Centre (CA)
- Yale University (US)
- Fred Hutch Cancer Center (US)
- Brain Tumour Research (GB)
- Seattle Children's Hospital (US)
- Center for Cancer and Blood Disorders (US)
- McGill University (CA)
- The Ohio State University (US)
Publication Details
- Journal
- Neuro-Oncology Advances
- Published
- 2025-11-13
- DOI
- https://doi.org/10.1093/noajnl/vdaf241
- Citations
- 1
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.63
Funders
- Cure Starts Now Foundation
- Stand Up To Cancer