TAMs-mediated resistance to oncolytic virus M1 in solid tumors
TAMs, particularly M1-like subsets, play a critical role in mediating resistance to OVM therapy by reducing viral persistence and suppressing CD8<sup>+</sup> T-cell responses. Targeting TAMs significantly improves the antitumor efficacy of OVM in solid tumors. These findings support the development of TAMs-targeted combination strategies to optimize oncolytic virotherapy.
Authors
- Ke Sai (ORCID: https://orcid.org/0000-0003-1762-9019)
- C. Chen (ORCID: https://orcid.org/0000-0003-2345-1915)
- Jingjie Li (ORCID: https://orcid.org/0009-0004-2847-4184)
- Cui Guo
- Wenfeng Liu (ORCID: https://orcid.org/0009-0005-2547-4442)
- Chris Yan (ORCID: https://orcid.org/0009-0002-8566-2021)
- H.-G. Li (ORCID: https://orcid.org/0000-0001-9632-4859)
- Guangmei Yan (ORCID: https://orcid.org/0000-0002-8822-2657)
- Yuan Lin (ORCID: https://orcid.org/0000-0002-7152-0965)
- Ying Liu (ORCID: https://orcid.org/0009-0002-2364-2623)
- Wenbo Zhu (ORCID: https://orcid.org/0000-0002-9143-5733)
- Yu Han (ORCID: https://orcid.org/0009-0008-0672-4233)
- Xuanming Liang (ORCID: https://orcid.org/0009-0000-2023-9324)
- Jiehong Chen (ORCID: https://orcid.org/0009-0008-1594-7180)
Institutions
- Sun Yat-sen University (CN)
- Sixth Affiliated Hospital of Sun Yat-sen University (CN)
- Sun Yat-sen University Cancer Center (CN)
- Third Affiliated Hospital of Sun Yat-sen University (CN)
Publication Details
- Journal
- Journal for ImmunoTherapy of Cancer
- Published
- 2025-11-01
- DOI
- https://doi.org/10.1136/jitc-2025-012858
- Primary Topic
- Virus-based gene therapy research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Yuhan
- National Natural Science Foundation of China
- Basic and Applied Basic Research Foundation of Guangdong Province