A single-cell multi-omics framework identifies immune cell drivers of migraine and repurposable therapeutics
This study establishes an extensible multi-omics analytical framework, providing novel insights into the immunogenetic basis of migraine. Furthermore, it successfully identified repurposable candidate drugs targeting key pathogenic genes, offering new perspectives for developing novel immunomodulatory therapeutic strategies for migraine.
Authors
- Yanxun Han (ORCID: https://orcid.org/0009-0003-6412-2568)
- Li Wang (ORCID: https://orcid.org/0000-0003-4337-3547)
- Dapeng Li (ORCID: https://orcid.org/0000-0003-0571-5876)
- Ye Tao (ORCID: https://orcid.org/0000-0002-0165-970X)
- Chun‐Bo Feng
Institutions
- Anhui Medical University (CN)
- Bozhou People's Hospital (CN)
- First Affiliated Hospital of Anhui Medical University (CN)
Publication Details
- Journal
- The Journal of Headache and Pain
- Published
- 2025-11-13
- DOI
- https://doi.org/10.1186/s10194-025-02179-w
- Citations
- 2
- Primary Topic
- Migraine and Headache Studies
- Type
- article
- Field-Weighted Citation Impact
- 2.94
Funders
- National Natural Science Foundation of China
- Anhui Medical University