Prevalence of 3,4-Methylenedioxy-α-Pyrrolidinohexanophenone (3,4-MDPHP) in 465 Suspected Intoxication Cases and Cross-Reactivity Evaluation in an Ecstasy Immunoassay

This study confirms the high prevalence (108/465) of 3,4-MDPHP in NPS related intoxication cases in our cohort. It is essential for clinical laboratories and emergency departments to be aware of the potential cross-reactivity in ecstasy immunoassay, as this may lead to significant diagnostic errors and misinterpretation of results.

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Publication Details

Journal
The Journal of Applied Laboratory Medicine
Published
2025-11-05
DOI
https://doi.org/10.1093/jalm/jfaf165
Primary Topic
Forensic Toxicology and Drug Analysis
Type
article
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article

Prevalence of 3,4-Methylenedioxy-α-Pyrrolidinohexanophenone (3,4-MDPHP) in 465 Suspected Intoxication Cases and Cross-Reactivity Evaluation in an Ecstasy Immunoassay

Ilaria Giardini, A. Valli, Azzurra Schicchi, Mariapina Gallo et al.
The Journal of Applied Laboratory Medicine
Forensic Toxicology and Drug Analysis
article

Prevalence of 3,4-Methylenedioxy-α-Pyrrolidinohexanophenone (3,4-MDPHP) in 465 Suspected Intoxication Cases and Cross-Reactivity Evaluation in an Ecstasy Immunoassay

Ilaria Giardini, A. Valli, Azzurra Schicchi, Mariapina Gallo, Maurizio Pasi, C. Locatelli, Eleonora Buscaglia, Andrea Giampreti, Riccardo Albertini, Pietro Papa
article en

Abstract

This study confirms the high prevalence (108/465) of 3,4-MDPHP in NPS related intoxication cases in our cohort. It is essential for clinical laboratories and emergency departments to be aware of the potential cross-reactivity in ecstasy immunoassay, as this may lead to significant diagnostic errors and misinterpretation of results.

The Journal of Applied Laboratory MedicineVol. 11(1)
Istituti Clinici Scientifici Maugeri (IT), Ospedale Papa Giovanni XXIII (IT), Policlinico San Matteo Fondazione (IT)
Openalex Percentile: Top 66%
Forensic Toxicology and Drug Analysis
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Prevalence of 3,4-Methylenedioxy-α-Pyrrolidinohexanophenone (3,4-MDPHP) in 465 Suspected Intoxication Cases and Cross-Reactivity Evaluation in an Ecstasy Immunoassay — Ilaria Giardini, A. Valli, et al. · The Journal of Applied Laboratory Medicine (2025) | TGRS Research Map | TGRS