European Respiratory Society and European Society of Thoracic Surgeons clinical practice guideline on fitness for curative intent treatment of lung cancer
A multidisciplinary panel of lung cancer experts with a special interest in functional evaluation of lung cancer patients, and lung cancer patient representatives, has been facilitated by the European Society of Thoracic Surgeons and the European Respiratory Society to provide healthcare professionals with practical and up-to-date recommendations for the assessment of patients' fitness for curative intent treatments for lung cancer. The panel formulated four PICO (population, intervention, comparison and outcomes) questions and seven complementary narrative questions. Both types of questions were assigned to groups of at least two experts. A medical librarian conducted the literature searches, and the authors selected relevant studies based on predefined inclusion criteria. Risk of bias was assessed using the QUIPS (Quality in Prognosis Studies) tool. Data were summarised and the certainty of evidence was assessed with GRADE (Grading of Recommendations, Assessment, Development and Evaluations) and the Evidence to Decisions framework was used to formulate recommendations. A series of multidisciplinary recommendations was formulated about the utilisation of pulmonary function tests, split lung function values, exercise tests, cardiologic testing, and the role of prehabilitation, sublobar resections, risk scores and comorbidities in selecting patients for curative intent treatment.
Authors
- Georgia Hardavella
- Thierry Berghmans (ORCID: https://orcid.org/0000-0001-7447-2519)
- Rudolf M. Huber (ORCID: https://orcid.org/0000-0001-7041-6368)
- Wouter Heero van Geffen (ORCID: https://orcid.org/0000-0002-5976-0974)
- Mark K. Ferguson (ORCID: https://orcid.org/0000-0001-6651-7668)
- Tim Batchelor (ORCID: https://orcid.org/0000-0003-4103-6061)
- Corinne Faivre‐Finn (ORCID: https://orcid.org/0000-0001-5617-9781)
- Thomy Tonia (ORCID: https://orcid.org/0000-0001-7896-6188)
- Ilona Tietzova (ORCID: https://orcid.org/0000-0002-6736-1287)
- Clare Williams (ORCID: https://orcid.org/0000-0001-9446-0339)
- Daniël Langer
- Lieven Depypere (ORCID: https://orcid.org/0000-0001-8230-5649)
- Edward Caruana (ORCID: https://orcid.org/0000-0002-0257-7618)
- Nuria Novoa (ORCID: https://orcid.org/0000-0003-0124-6347)
- Ismini Kourouni
- Cecilia Pompili (ORCID: https://orcid.org/0000-0001-6746-5441)
- Janette Rawlinson (ORCID: https://orcid.org/0000-0002-9536-9809)
- Nándor Marczin (ORCID: https://orcid.org/0000-0003-3690-5891)
- Valérie Durieux (ORCID: https://orcid.org/0000-0002-8975-6562)
- Dirk De Ruysscher (ORCID: https://orcid.org/0000-0001-9269-6567)
- Ulrich Mansmann (ORCID: https://orcid.org/0000-0002-9955-8906)
- Marianne Paesmans
- Vincent Fallet (ORCID: https://orcid.org/0000-0002-5153-6951)
- Blin Nagavci (ORCID: https://orcid.org/0000-0002-6626-2842)
- Riccardo Asteggiano (ORCID: https://orcid.org/0000-0002-2273-7228)
- Armin Frille (ORCID: https://orcid.org/0000-0003-2843-3863)
- Andrew Creamer (ORCID: https://orcid.org/0000-0002-9314-1210)
- Annemiek Snoeckx (ORCID: https://orcid.org/0000-0003-2101-2783)
- Pınar Akın Kabalak (ORCID: https://orcid.org/0000-0002-4087-7048)
- Torsten Gerriet Blum (ORCID: https://orcid.org/0000-0003-1216-2157)
- Diego Kauffmann‐Guerrero (ORCID: https://orcid.org/0000-0003-1471-3290)
- Alessandro Brunelli (ORCID: https://orcid.org/0000-0002-6505-1656)
- Maria Rodriguez (ORCID: https://orcid.org/0000-0003-4093-5292)
- Adrien Costantini
- Amani Al Tawil
- Nora Alhannoush
Institutions
- Semmelweis University (HU)
- University of Insubria (IT)
- University of Bern (CH)
- St Bartholomew's Hospital (GB)
- Université Libre de Bruxelles (BE)
- Zimmer Biomet (Netherlands) (NL)
- University of Health Science (KH)
- University of Hull (GB)
- Charles University (CZ)
- Royal Brompton & Harefield NHS Foundation Trust (GB)
- University Medical Center Freiburg (DE)
- St James's University Hospital (GB)
- British Lung Foundation (GB)
- Institut Jules Bordet (BE)
- Glenfield Hospital (GB)
- Medisch Centrum Leeuwarden (NL)
- Harefield Hospital (GB)
- University of Manchester (GB)
- Maastricht University (NL)
- Sorbonne Université (FR)
- University of Chicago (US)
- MSB Medical School Berlin (DE)
- Ankara Atatürk Eğitim ve Araştırma Hastanesi (TR)
- Royal Brompton Hospital (GB)
- Assistance Publique – Hôpitaux de Paris (FR)
- Chest Diseases Hospital (KW)
- Helios Klinikum Emil von Behring (DE)
- Antwerp University Hospital (BE)
- Hospital Universitario Puerta de Hierro Majadahonda (ES)
- Imam Abdulrahman Al Faisal Hospital (SA)
- University Hospital Leipzig (DE)
- Sağlık Bilimleri Üniversitesi (TR)
- German Center for Lung Research (DE)
- Cancer Research UK Manchester Institute (GB)
- British Steel (United Kingdom) (GB)
- Hôpital Ambroise-Paré (FR)
- The Christie NHS Foundation Trust (GB)
- Clinica Universidad de Navarra (ES)
- Institute of Social and Preventive Medicine (CH)
- Lung Foundation Netherlands (NL)
- Thomayer University Hospital (CZ)
- The London College (GB)
- Erasmus MC Cancer Institute (NL)
- MetroHealth Medical Center (US)
- Maastro Clinic (NL)
- General University Hospital in Prague (CZ)
- Sotiria General Hospital (GR)
- Hôpital Tenon (FR)
- University College London (GB)
- Imperial College London (GB)
- University of Turin (IT)
- Imam Abdulrahman Bin Faisal University (SA)
- Ludwig-Maximilians-Universität München (DE)
- Leipzig University (DE)
- KU Leuven (BE)
Publication Details
- Journal
- European Journal of Cardio-Thoracic Surgery
- Published
- 2025-11-01
- DOI
- https://doi.org/10.1093/ejcts/ezaf329
- Citations
- 1
- Primary Topic
- Lung Cancer Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.52