Searching for physical principles of morphogenesis

In morphogenesis, biology uses physics to sculpt organs. Understanding this fascinating process requires interdisciplinary collaboration. We highlight recent work in the 'physics of development', with a focus on the interplay between quantitative experiments and mathematical theory. We argue that the role of theory in developmental biology lies in identifying and describing dynamical mechanisms - from the processing of positional information to mechanical pattern formation - independently of their molecular implementation. This level of abstraction provides a structured approach to embrace developmental complexity, but can propose experimental tests to verify its key tenets. We conclude with a sketch of future research perspectives in emerging synthetic morphogenesis systems, which may serve as a platform to distill principles of developmental self-organization.

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Publication Details

Journal
Development
Published
2025-11-01
DOI
https://doi.org/10.1242/dev.204894
Primary Topic
Planarian Biology and Electrostimulation
Type
article
Field-Weighted Citation Impact
0.00

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article

Searching for physical principles of morphogenesis

Fridtjof Brauns, Nikolas H Claussen, Sebastian J. Streichan
Development
Planarian Biology and Electrostimulation
article

Searching for physical principles of morphogenesis

Fridtjof Brauns, Nikolas H Claussen, Sebastian J. Streichan
article en

Abstract

In morphogenesis, biology uses physics to sculpt organs. Understanding this fascinating process requires interdisciplinary collaboration. We highlight recent work in the 'physics of development', with a focus on the interplay between quantitative experiments and mathematical theory. We argue that the role of theory in developmental biology lies in identifying and describing dynamical mechanisms - from the processing of positional information to mechanical pattern formation - independently of their molecular implementation. This level of abstraction provides a structured approach to embrace developmental complexity, but can propose experimental tests to verify its key tenets. We conclude with a sketch of future research perspectives in emerging synthetic morphogenesis systems, which may serve as a platform to distill principles of developmental self-organization.

DevelopmentVol. 152(21)
University of California, Santa Barbara (US)
National Science Foundation, Gordon and Betty Moore Foundation, University of California, Santa Barbara
Openalex Percentile: Top 70%
Planarian Biology and Electrostimulation
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