Electrochemical Cross-Coupling of P(O)-H with Thioesters: Green Synthesis of Phosphorothioates
An efficient and eco-friendly electrochemical strategy enables the metal-, base-, and oxidant-free cross-coupling between thioesters and P(O)-H species for the construction of P-S bonds. The reaction proceeds under mild conditions and has a broad substrate scope (61 examples, up to 95%). Even in gram-scale synthesis, satisfactory yields can be achieved. The utilization of thioesters circumvents traditional procedures that involve gaseous short-chain alkyl thiols. Meanwhile, it offers a practical alternative to malodorous and unstable thiols.
Authors
- Pingping Tang (ORCID: https://orcid.org/0000-0002-8296-5695)
- Fanhua Meng
- Wenying Guo (ORCID: https://orcid.org/0009-0002-0788-5932)
- Yongbiao Guo (ORCID: https://orcid.org/0000-0001-7284-6775)
- Zirui Lv (ORCID: https://orcid.org/0009-0006-4738-7339)
- Lihua Huang (ORCID: https://orcid.org/0000-0003-0768-2369)
- Zhenhua Gao (ORCID: https://orcid.org/0000-0001-5073-1985)
- Xiandong Dai
- Chunru Cheng (ORCID: https://orcid.org/0000-0002-6991-3313)
Institutions
- State Council of the People's Republic of China (CN)
- Sichuan University of Science and Engineering (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-11-12
- DOI
- https://doi.org/10.1021/acs.orglett.5c03772
- Citations
- 3
- Primary Topic
- Sulfur-Based Synthesis Techniques
- Type
- article
- Field-Weighted Citation Impact
- 2.81