Early prediction of gestational diabetes mellitus using machine learning-integrated metabolomic and clinical features

Participants with GDM and NGT show great difference in the levels of many metabolites. The ML model according to the metabolites in the first trimester and clinical feature demonstrates high accuracy for early GDM prediction. The result of this research highlighted the potential of metabolites in the prediction of GDM in the early stage of pregnancy.

Authors

Lan Gao (ORCID: https://orcid.org/0000-0002-7034-6379)
Yingbei Lin
Bidong Fu
Qun Ji (ORCID: https://orcid.org/0009-0002-1104-8846)
Fei Wang (ORCID: https://orcid.org/0000-0002-5676-2181)
Xiaofang Chen (ORCID: https://orcid.org/0009-0003-1521-4431)
Haiwei Liu (ORCID: https://orcid.org/0000-0001-8666-4462)

Institutions

Hainan General Hospital (CN)
Hainan Medical University (CN)

Publication Details

Journal: Frontiers in Endocrinology
Published: 2025-11-13
DOI: https://doi.org/10.3389/fendo.2025.1687146
Primary Topic: Gestational Diabetes Research and Management
Type: article
Field-Weighted Citation Impact: 0.00

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article

Early prediction of gestational diabetes mellitus using machine learning-integrated metabolomic and clinical features

Lan Gao, Yingbei Lin, Bidong Fu, Qun Ji et al.

Nov 13, 2025

Frontiers in Endocrinology

Gestational Diabetes Research and Management

article

Early prediction of gestational diabetes mellitus using machine learning-integrated metabolomic and clinical features

Lan Gao, Yingbei Lin, Bidong Fu, Qun Ji, Fei Wang, Xiaofang Chen, Haiwei Liu

November 13, 2025article en

Abstract

Participants with GDM and NGT show great difference in the levels of many metabolites. The ML model according to the metabolites in the first trimester and clinical feature demonstrates high accuracy for early GDM prediction. The result of this research highlighted the potential of metabolites in the prediction of GDM in the early stage of pregnancy.

Frontiers in EndocrinologyVol. 16

Hainan General Hospital (CN), Hainan Medical University (CN)

Openalex Percentile: Top 57%

Gestational Diabetes Research and Management

DOI Open Access PDF OpenAlex

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