Waning Protection Against Severe COVID-19 Following Vaccination: A Longitudinal IPTW Analysis of Emergency Department Encounters

COVID-19 vaccination provides sustained protection against severe outcomes for up to 18 months, after which effectiveness declines substantially. These findings support booster dose strategies based on time since last vaccination and targeted prioritization for high-risk populations.

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Publication Details

Journal
Infectious Disease Reports
Published
2025-11-13
DOI
https://doi.org/10.3390/idr17060142
Primary Topic
SARS-CoV-2 and COVID-19 Research
Type
article
Field-Weighted Citation Impact
0.00
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article

Waning Protection Against Severe COVID-19 Following Vaccination: A Longitudinal IPTW Analysis of Emergency Department Encounters

Amit Bahl, Yuying Xing
Infectious Disease Reports
SARS-CoV-2 and COVID-19 Research
article

Waning Protection Against Severe COVID-19 Following Vaccination: A Longitudinal IPTW Analysis of Emergency Department Encounters

Amit Bahl, Yuying Xing
article en

Abstract

COVID-19 vaccination provides sustained protection against severe outcomes for up to 18 months, after which effectiveness declines substantially. These findings support booster dose strategies based on time since last vaccination and targeted prioritization for high-risk populations.

Infectious Disease ReportsVol. 17(6)
Oakland University (US), Beaumont Health (US), Beaumont Hospital, Royal Oak (US)
Openalex Percentile: Top 60%
SARS-CoV-2 and COVID-19 Research
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