Neutralizing IL-22RA1 improves histologic and molecular alterations associated with atopic dermatitis pathogenesis
These findings suggest that the IL-22/IL-22RA1 axis functionally contributes to AD pathogenesis. Thus, blocking IL-22RA1 represents a potentially valuable new therapeutic option.
Authors
- Birgitte Ursoe
- Sophia Wasserer
- Felix Lauffer (ORCID: https://orcid.org/0000-0002-1992-2836)
- Christina Hillig (ORCID: https://orcid.org/0000-0001-7447-547X)
- Mette Sidsel Mortensen
- Tine Skak‐Nielsen
- Christophe Blanchetot (ORCID: https://orcid.org/0000-0001-9152-9978)
- Natalie Garzorz‐Stark (ORCID: https://orcid.org/0000-0002-7409-7883)
- Michael P. Menden (ORCID: https://orcid.org/0000-0003-0267-5792)
- Josephine B. Hebsgaard (ORCID: https://orcid.org/0000-0001-6761-0186)
- Stefanie Eyerich (ORCID: https://orcid.org/0000-0002-1166-2355)
- Anna Caroline Pilz (ORCID: https://orcid.org/0000-0002-3028-4556)
- Tilo Biedermann (ORCID: https://orcid.org/0000-0002-5352-5105)
- Britta C. Martel
- Thomas Litman (ORCID: https://orcid.org/0000-0002-6068-901X)
- Manja Jargosch (ORCID: https://orcid.org/0000-0001-6051-4036)
- Kilian Eyerich (ORCID: https://orcid.org/0000-0003-0094-2674)
- Malene Bertelsen
Institutions
- Ablynx (Belgium) (BE)
- University of Freiburg (DE)
- University Medical Center Freiburg (DE)
- Helmholtz Zentrum München (DE)
- München Klinik (DE)
- Leo Pharma (Denmark) (DK)
- Technical University of Munich (DE)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- Journal of Allergy and Clinical Immunology
- Published
- 2025-11-13
- DOI
- https://doi.org/10.1016/j.jaci.2025.08.033
- Citations
- 2
- Primary Topic
- Dermatology and Skin Diseases
- Type
- article
- Field-Weighted Citation Impact
- 4.01