Shunt magnitude is a key determinant of overt hepatic encephalopathy in patients undergoing TIPS
TIPS carries a significant risk of overt hepatic encephalopathy. Low portosystemic pressure gradient and larger shunt diameter have been reported to increase the risk of overt hepatic encephalopathy. The TIPS dilation diameter represents an independent key determinant of post-TIPS overt hepatic encephalopathy. Thus, TIPS under-dilation reduces overt hepatic encephalopathy occurrence while effectively controlling portal hypertension complications even without meeting established hemodynamic targets.
Authors
- Davide Roccarina (ORCID: https://orcid.org/0000-0002-1224-5502)
- Kymentie Ferdinande (ORCID: https://orcid.org/0009-0004-1554-1739)
- Melania Gaggini (ORCID: https://orcid.org/0000-0002-6311-502X)
- Chiara Mangini (ORCID: https://orcid.org/0000-0002-9312-0372)
- Stefania Gioia (ORCID: https://orcid.org/0000-0002-3940-4390)
- Lorenzo Ridola (ORCID: https://orcid.org/0000-0002-8596-2609)
- Marco Senzolo (ORCID: https://orcid.org/0000-0002-7261-6520)
- Tomas Guasconi
- Federico Casari (ORCID: https://orcid.org/0000-0001-9914-225X)
- Francesco Vizzutti (ORCID: https://orcid.org/0000-0002-3014-8968)
- Gianmarco Falcone (ORCID: https://orcid.org/0009-0000-5612-7797)
- Marcello Bianchini (ORCID: https://orcid.org/0000-0003-4615-3777)
- Linda Ragozzino
- Martina Rosi (ORCID: https://orcid.org/0000-0001-6601-4737)
- Stefano Gitto (ORCID: https://orcid.org/0000-0002-8042-6508)
- Filippo Schepis (ORCID: https://orcid.org/0000-0001-6549-5102)
- U. Arena (ORCID: https://orcid.org/0000-0002-8839-1506)
- Sara Montagnese (ORCID: https://orcid.org/0000-0003-2800-9923)
- Angelica Ingravallo
- Dario Saltini (ORCID: https://orcid.org/0009-0007-3054-7575)
- Valentina Adotti (ORCID: https://orcid.org/0000-0003-3639-0509)
- Silvia Aspite
- Lara Biribin
- Fabrizio Fanelli (ORCID: https://orcid.org/0000-0002-5273-0609)
- Cristian Caporali (ORCID: https://orcid.org/0000-0003-1148-1383)
- Fabio Marra (ORCID: https://orcid.org/0000-0001-8629-0878)
- Silvia Nardelli (ORCID: https://orcid.org/0000-0002-7038-9539)
- Oliviero Riggio (ORCID: https://orcid.org/0000-0003-0241-3223)
- Margherita Falcini
- Manuela Merli (ORCID: https://orcid.org/0000-0003-3173-9767)
- A. Piscopo (ORCID: https://orcid.org/0009-0006-9873-8813)
- Francesco Pindozzi
Institutions
- University of Modena and Reggio Emilia (IT)
- University of Padua (IT)
- The Royal Free Hospital (GB)
- Istituto di Fisiologia Clinica (IT)
- Azienda Ospedaliero-Universitaria di Modena (IT)
- Azienda Ospedaliero-Universitaria Careggi (IT)
- National Research Council (IT)
- University of Florence (IT)
- University College London (GB)
- Sapienza University of Rome (IT)
Publication Details
- Journal
- JHEP Reports
- Published
- 2025-11-13
- DOI
- https://doi.org/10.1016/j.jhepr.2025.101676
- Citations
- 1
- Primary Topic
- Liver Disease and Transplantation
- Type
- article
- Field-Weighted Citation Impact
- 1.32
Funders
- Università degli Studi di Firenze