Characterization of Staphylococcus aureus Small-Colony Variants Isolated from Lower Respiratory Tract Specimens
This study identified a 2.1% prevalence of <i>S. aureus</i> SCVs (often undetected) in <i>P. aeruginosa</i> pneumonia patients. More than half of patients were methicillin-resistant (MRSA), with strong biofilm-forming capacity and a potential association with prolonged hospitalization. Vigilance is warranted against potential outbreaks of the predominant MRSA-SCV clone ST1-t128, as well as the severe drug resistance observed in ST764-t1084 MRSA-SCVs.
Authors
- Shanjian Chen
- Chao An (ORCID: https://orcid.org/0000-0003-4029-2709)
- Baijian Wu (ORCID: https://orcid.org/0000-0002-5738-6595)
- Yulan Lin
- Chen Ruan (ORCID: https://orcid.org/0009-0008-5844-5092)
- Bin B. Yang (ORCID: https://orcid.org/0000-0003-4452-6453)
- Shenghua Zou
- Chenshuo Luo
Institutions
- Fujian Medical University (CN)
- First Affiliated Hospital of Fujian Medical University (CN)
- Fuzhou Pulmonary Hospital of Fujian (CN)
Publication Details
- Journal
- Infection and Drug Resistance
- Published
- 2025-11-01
- DOI
- https://doi.org/10.2147/idr.s556503
- Primary Topic
- Antimicrobial Resistance in Staphylococcus
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China