Prognostic Value of Neutrophil-to-Lymphocyte Ratio, Platelet-to-Lymphocyte Ratio, and Lactate Dehydrogenase Level in Melanoma Patients Treated with Immune Checkpoint Inhibitors
ECOG PS ≥2 and elevated NLR were associated with no clinical benefit, while elevated NLR and LDH independently predicted poorer survival. These markers may serve as practical prognostic tools in metastatic melanoma treated with ICIs.
Authors
- Afaf Abed (ORCID: https://orcid.org/0000-0001-7506-3362)
- Oliver Oey (ORCID: https://orcid.org/0000-0003-0673-6804)
- Wynne Wijaya (ORCID: https://orcid.org/0000-0003-2111-9839)
- Elin S. Gray (ORCID: https://orcid.org/0000-0002-8613-3570)
- Tarek Meniawy (ORCID: https://orcid.org/0000-0002-1457-6137)
- Michael Millward (ORCID: https://orcid.org/0000-0002-1744-1617)
- Muhammad Adnan Khattak
Institutions
- Edith Cowan University (AU)
- The University of Western Australia (AU)
- Fiona Stanley Hospital (AU)
- Sir Charles Gairdner Hospital (AU)
- University of Oxford (GB)
Publication Details
- Journal
- Cancer Investigation
- Published
- 2025-11-13
- DOI
- https://doi.org/10.1080/07357907.2025.2586257
- Primary Topic
- Inflammatory Biomarkers in Disease Prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00