Quantification and detection of Mycobacterium tuberculosis, HIV-1 co-localization, and reciprocal expansion in spinal tuberculosis tissues
DdPCR has high sensitivity for STB diagnosis. Confirming reciprocal relationships exists between Mtb and HIV-1 abundance in spinal tissue in PLWH on ART, supports characterizing the immune microenvironment in co-infected tissue sites to elucidate factors that impact HIV-1/Mtb reservoir persistence and/or expansion.
Authors
- Michael Held (ORCID: https://orcid.org/0000-0002-0671-0439)
- Adrian R. Martineau (ORCID: https://orcid.org/0000-0001-5387-1721)
- Anna K. Coussens (ORCID: https://orcid.org/0000-0002-7086-2621)
- Melissa-Rose Abrahams (ORCID: https://orcid.org/0000-0002-1907-4929)
- Robert Dunn (ORCID: https://orcid.org/0000-0002-3689-0346)
- Robyn Waters (ORCID: https://orcid.org/0000-0002-1101-6062)
- Maritz Laubscher (ORCID: https://orcid.org/0000-0002-5989-8383)
Institutions
- University of Cape Town (ZA)
- Queen Mary University of London (GB)
- Walter and Eliza Hall Institute of Medical Research (AU)
- Groote Schuur Hospital (ZA)
- Wellcome Centre for Infectious Diseases Research in Africa (ZA)
Publication Details
- Journal
- International Journal of Infectious Diseases
- Published
- 2025-11-13
- DOI
- https://doi.org/10.1016/j.ijid.2025.108204
- Primary Topic
- Infectious Diseases and Tuberculosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- University of Cape Town
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases